- K. G. Kanase
- N. V. Shinde
- D. K. Bharti
- V. R. Undale
- Dhavale Sushant Saindra
- Rajesh Jagtap
- Tushar Kotkar
- S. R. Hardikar
- R. K. Dumbre
- A. P. Kale
- V. R. Patil
- M. B. Kamble
- M. M. Abhyankar
- S. J. Pawar
- Khan Shoeb
- Naresh Patil
- Sharda Sonawane
- Deepak Bharati
- S. A. Sonawane
- M. M. Abhynkar
- R. S. Jagtap
- S. A. Sonawame
- V. P. Godse
- M. N. Deodhar
- R. A. Sonawane
- P. S. Sakpal
- D. D. Borkar
- Y. S. Bafana
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Bhosale, A. V.
- Diabetes Macroangiopathy - A Review
Authors
1 Department of Pharmacology, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Taluka: Purandar, Pune 412301, IN
2 Seth Govind Raghunath Sable College of Pharmacy, Saswad, Taluka: Purandar, Pune 412301, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 2 (2009), Pagination: 45-49Abstract
Diabetes mellitus, a metabolic disorder characterised by high levels of blood glucose, is associated with several vascular complications. Although insulin treatment, oral medications, dietary regulations and exercise can delay the development of diabetic microangiopathy, the development of macroangiopathy cannot be prevented solely by glycaemic control. However, diabetic-macroangiopathy refers mainly to an accelerated form of atherosclerosis. This in turn affects both the coronary and cerebral vasculature, thus increasing the risk of myocardial infarction, angina pectoris and cerebrovascular accidents. Diabetes mellitus in humans and animal models of diabetes are associated with impaired endothelium-dependent relaxation i.e. endothelial dysfunction. Endothelial dysfunction, a surrogate marker for the development of diabetic macroangiopathy.Keywords
Diabetes Mellitus, Endothelial Dysfunction, Hyperglycemia, Oxidative Stress.
References
- The Diabetes Control and Complications Trial (DCCT) Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329: 977-986
- Barar, F.S.K. Essentials of Pharmacotherapeutics, S.Chand publication, 2003; 3rd ed: pp 340-346.
- Harsh Mohan. Text book of Pathophysiology, Diabetes complications Jaypee brother publishers Ltd.1998; 3rd ed: 972-978.
- Antonio Ceriello. Oxidative stress and diabetes associated complications, Endocrine practice 2006; 12: 60-61.
- Ulvi Bayraktutan. Free Radicals, Diabetes and Endothelial Dysfunction, Department of Medicine, Institute of Clinical Science Block B, UK,1-15.
- Brownlee M. The pathobiology of diabetic complications. A unifying mechanism. Diabetes 2005; 54: 1615-25.
- UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes. UKPDS 38. BMJ 1998; 317: 703-13.
- Rossing P. The changing epidemiology of diabetic microangiopathy in type 1 diabetes. Diabetologia 2005; 48:143944.
- Gaziano, J.M. Global Burden of cardiovascular disease, In Braunwald E, Ipes D.P and Libby P, Heart disease a textbook of cardiovascular medicine, 1-17.
- Nathan, M.N, Singer, D.E. The epidemiology of cardiovascular disease in type 2 diabetes mellitus:How sweet it is...or is it? Lancet, 4-9.
- Stamler. J, Vacaro. O, Neaton. J. For the Multiple Risk Factor Intervention Trial Research group,Diabetes other risk factors and 12th year cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial,434- 444.
- Turner R.C,The U.K.Prospective study: A review, C35-38.
- Feener,E.P,and King,G.L,Vascular dysfunction in diabetes mellitus,9-13.
- Wei.M, Haffner.S.M, Effect of diabetes and level of ischemia on all causes and cardiovascular mortality, 1167-1172.
- Kannel.R, McGee.D.L, Diabetes and cardiovascular disease, Journal of the American Medical Association, 2035-2038.
- Meigs.J.B, Mittleman.M.A., Nathan.D.M, Singer.D.E, Hyperinsulinemia, hyperglycemia and impaired hemostasis. Journal of the American Medical Associations, 221-228.
- Formulation and Evaluation of Floating Sustained Drug Delivery for Metformin HCl Using Combination of Natural and Synthetic Polymers
Authors
1 Ganesh Complex B-7/1 Manikbaug, Sinhagad Road, Pune-411051 (Maharashtra), IN
2 Department Of Pharmaceutics, PDEA'S SGRS College Of Pharmacy, Saswad, Tal-Purandar, Dist-Pune, Mh-412301
3 Department Of Pharmaceutics, PDEA’S SGRS College Of Pharmacy, Saswad, Tal-Purandar, Dist-Pune, Mh-412301
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 3 (2009), Pagination: 244-249Abstract
Metformin hydrochloride is an oral anti-hyperglycemic drug that has long been used in the management of non-insulin-dependent diabetes mellitus. Absorption of metformin hydrochloride is confined to the small intestine. Furthermore, conventional sustained-release dosage forms may be poorly bioavailable since absorption appears to cease or diminish when the dosage forms pass into the large intestine A conventional oral SR formulation releases most of the drug content at the colon, which requires that drug will be absorbed from the colon while metformin has poor colonic absorption.In the case of insufficient colonic absorption, clinical advantage may be acomplished by a SR-gastroretentive dosage form that is retained in the stomach and produces a constant input of the drug to the sites of absorption at the upper part of the gastrointestinal (GI) tract. In this study attempt was made to formulate floating sustained drug delivery system for Metformin HCl using combination of natural and synthetic polymer as Psyllium Husk and HPMC respectively. Sodium bicarbonate was added as a gas generating agent.FTIR and DSC study for Drug – Exciepient compatibility studies showed no interaction between Metformin HCl and polymers used. The granules prepared by wet granulation technique for sustained release layer of drug and polymers was evaluated for Angle of repose, Bulk Density, Tapped Density, Carr’s index and Hausner ratio which concluded that these were considerably good to formulate the tablets also the formulated batches showed good in-vitro floating ability throughout the study.Keywords
Metformin Hydrochloride, Floating Drug Delivery, Psyllium Husk, Hydroxypropyl Methyl Cellulose.- Effect of Arogyavardhini in Experimental Prostatic Hyperplasia and Inflammation in Rats
Authors
1 Plot no 430, Sector No 28, Nigdi Pradhikaran, Pune, Maharashtra, Pin 411044, IN
2 PDEA’s Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune, Maharashtra, IN
3 TVES’s Loksevak Madhukarrao Chaudhari College of Pharmacy, Faizpur, Maharashtra, IN
4 Rajgad Dyanpeeth’s College of Pharmacy, Bhor, Pune, Maharashtra, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 6 (2012), Pagination: 314-317Abstract
Arogyavardhini, an Ayurvedic herbomineral formulation, was studied for its effect in experimental prostatic hyperplasia induced by testosterone injection s.c for 21 days in rats and inflammation induced in rat hind paw by carrageenan injection s.c. The results showed that Arogyavardhini at dosage of 100, 200 and 400 mg/kg orally for 21 days showed significant reduction of prostatic hyperplasia as indicated by decreased prostate weight and volume and hispathological observations. It also significantly inhibited carrageenan induced hind paw oedema in dose dependant manner. These results suggest that Arogyavardhini is effective in prostate disorder like Benign Prostatic Hyperplasia (BPH) by inhibiting proliferative and inflammatory mechanisms in prostate.
Keywords
Arogyavardhini, Herbomineral Preparation, Ayurvedic Formulation, Prostatic Hyperplasia, Anti Inflammatory.- Nyctanthes arbortristis:A Pharmacognostic Review
Authors
1 Dept. of Pharmacognosy, PDEA’S SGRS College of Pharmacy, Saswad, IN
2 Dept. of Pharmacognosy, PDEA’S SGRS College of Pharmacy, Saswad, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 2 (2009), Pagination: 91-97Abstract
Nyctanthes arbortristis Linn. is one of the well known medicinal plant. It is a common wild hardy large shrub or small tree. It is a native of India, distributed wild in sub-Himalayan regions and southwards to Godavari. Different parts of this plant are used in Indian systems of medicine for various pharmacological actions. The rural people of Orissa use Nyctanthes arbortristis L. to cure various ailments. It's claimed traditional uses have been proved on scientific basis using invitro and in-vivo experiments. The present study will give comprehensive information on the chemical constituents and mainly pharmacological activities of this plant.Keywords
Nyctanthes arbour-tristis L., Pharmacology, Phytochemistry, Review.- Central Nervous System Depressant Activity of Ethanol Extract of Aerial Parts of Cynodon dactylon (L.) Pers. (Durva) in Mice
Authors
1 Department of Pharmacology, PDEA’S SGRS College of Pharmacy, Saswad, Tal-Purandar, Dist- Pune, Maharashtra, 412301, IN
2 Department of Pharmacology, PDEA’S SGRS College of Pharmacy, Saswad, Tal- Purandar, Dist- Pune, Maharashtra, 412301, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 2 (2009), Pagination: 119-122Abstract
Cynodon dactylon L. (Durva) a shrub from Poaceae family is popularly used in folk medicine for treating a wide variety of disorders in South and western India, China and central Asia. Aim of the study: To investigate the CNS depressant properties on experimental animals.
Materials and methods: ethanol extract of aerial parts of Cynodon dactylon (EECD) was studied to investigate its CNS depressant pharmacological properties in the classical behavioral models (openfield, elevated plus maze-EPM, Rota-rod, and Barbiturate-induced sleeping time) using mice. We decided to use i.p. administration of drugs because this pathway allows faster viability of the ethanol extract of aerial parts of Cynodon dactylon than oral pathway using 50% propylene glycol as a solvent in mice at single doses of 50, 75 and 100mg/kg.
Results: No significant effect was evident on motor coordination of the animals in the rotarod test. On EPM, all the doses of EECD presented a significant reduction on the time of permanence in the open arms, indicating an absence of anxiolytic-like effect. In addition, the EECD increased the immobility time in the forced swimming test and potentiated pentobarbital-induced sleeping time in mice, confirmed a probable sedative and central depressant effect in the animals.
Conclusion: Our results suggest that the ethanol extract of c. dactylon at 75mg/kg and 100mg/kg dose biologically active substance(s) that might be acting in the CNS and have significant depressant and anticonvulsant potentials, supporting folk medicine use of this plant.
Keywords
C. dactylon, Central Nervous System, EECD, EPM, FST.- Evaluation of Anti-Inflammatory, Antipyretic and Wound Healing Activity of Curcuma Inodora (Zingibaraceae)
Authors
1 PDEA’s SGRS College of Pharmacy, Saswad, Tal- Purandar, Dist- Pune, Mharashtra-412301, IN
2 Department of Pharmacology, PDEA’s SGRS College of Pharmacy, Saswad, Tal- Purandar. Dist-Pune, Maharashtra, 412301, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 1, No 1 (2009), Pagination: 35-40Abstract
Curcuma inodora is small Zingibarous herb and is used by the tribal's as a hair tonic and for cure of wounds. The objective of the present investigation was to study the selected dose of dried methanol extract of rhizomes of Curcuma inodora (200mg/kg i.p.) toward possible antiinflammatory, antipyretic and wound healing potential in experimental animal models. Anti-inflammatory potential of methanol extract was evaluated by carrageenan induced paw oedema and formalin induced paw oedema in rats. Also antipyretic and wound healing activity was also tested on animal models. The studies were conducted on Wistar rats of either sex (160-180 g). The change in oedema volume of the rat hind paw was measured using plethysmometer. The dried methanol extract of curcuma inodora (L.) inhibited the formation of paw oedema to significant levels in rats treated either with carrageenan or formalin. At a dose of 200 mg/kg orally, the dried methanol extract produced 74% inhibition in case of the carrageenan-induced oedema (P<0.01), and there was 79.61% inhibition in formalin-induced oedema (P<0.01).
Dried methanol extract of Curcuma inodora was also evaluated for antipyretic activity on animals as per Vogel's method. Curcuma inodora elicited a dose dependant inhibition of rectal temperature compared with control group. Dried methanol extract of Curcuma inodora produced 38.31 % inhibition at 200 mg/kg dose with a maximal inhibition 44.06 % at same dose which was compared with standard inhibition at 100 mg/kg p.o.
In excision wound model, 10% ointment of ethanol extract of C. inodora was evaluated for wound healing activity. The result showed that ethanol extract ointment possesses a definite pro-healing action. This was demonstrated by a significant increase in the rate of wound contraction and by enhanced epithelialization.
The results indicated that the dried methanol extract of the rhizomes was active against all the experimentally induced laboratory models of inflammation, pyrexia and wound healing.
- Chemo Informatics:Newer Approach for Drug Development
Authors
1 S.G.R.S College of Pharmacy, Saswad, Pune-413302, Maharashtra, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 1-7Abstract
Chemo informatics is a scientific discipline that has evolved in the last 40 years at the interface between chemistry and computer science. It has been realized that in many areas of chemistry, the huge amount of data and information produced by chemical research can only be processed and analyzed by computer methods. Furthermore, many of the problems faced in chemistry are so complex that novel approaches utilizing solutions that are based on informatics methods are needed. Thus, methods were developed for building databases on chemical compounds and reactions, for the prediction of physical, chemical and biological properties of compounds and materials, for drug design, for structure elucidation, for the prediction of chemical reactions and for the design of organic syntheses.Keywords
Chemi Informatics, Drug Development, Structure Activity Relationship.- Simultaneous Spectrophotometric Estimation of Ezetimibe and Atorvastatin in Pharmaceutical Dosage Form
Authors
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 1 (2009), Pagination: 86-89Abstract
Two simple, sensitive accurate, precise, rapid and economical methods were developed for the estimation of Ezetimibe and Atorvastatin in two components solid dosage form. First method is based on simultaneous equations and second method is based on absorbance ratio method. Ezetimibe has absorbance maxima at 232.5 nm and Atorvastatin has Absorbance maxima at 246.5 nm in methanol. The linearity was obtained in the concentration range 5-30 mcg/ml for both Ezetimibe and Atorvastatin. In the first method the concentration of the drugs were determined by using simultaneous equations and in second method, concentration of the drugs were determined by using ratio of absorbance at iso-absorptive point and at λmax of one of the drug. The results of analysis have been validated statistically and by recovery studies.Keywords
Ezetimibe, Atorvastatin, Simultaneous Equations, Absorbance Ratio, Iso-Absorptive Point.- Reverse Phase HPLC Method for Determination of Aceclofenac and Paracetamol in Tablet Dosage Form
Authors
1 Dept. of Pharmaceutical Analysis, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Pune-412301, IN